RIPK1-dependent mitophagy: A novel mechanism to eliminate cells detached from the extracellular matrix

For cancer cells to survive during extracellular matrix (ECM)-detachment, they must ORGANIC CONCORD GRAPE inhibit anoikis and rectify metabolic deficiencies that lead to the induction of non-apoptotic cell death.Here, we Phone Mount highlight and discuss our recent study implicating receptor-interacting protein kinase-1 (RIPK1) in the induction of mitophagy, the production of reactive oxygen species (ROS) and the consequent elimination of ECM-detached cells.